Articles, Graduate School of Medical Sciences, Tokushima University, Japan. All authors: contributed to the article and approved the submitted version. Thirdly, patients with higher T-Bil was very small which might increase the bias of the study. The two years line is equivalent to journal impact factor ™ (Thomson Reuters) metric. Atherosclerosis. Journals range from life sciences and health to engineering, robotics and humanities. In this study, STEMI was defined based on symptoms (i.e., continuous chest pain lasting >30 min), electrocardiography (ECG) finding (i.e., ST-segment elevation > 0.1 mV on an 18-lead ECG), and laboratory testing (i.e., increasing cardiac troponin I level) (10). Total bilirubin based Risk Score for MACE. This study was supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2016-I2M-1–009) and National Natural Science Funds (81970308). The high TBil group (n = 143) was composed of patients who had a TBil value in the third tertile (>22 μmmol/L), and the low TBil group (n = 3,565) was composed of patients who had a TBil value in the lower two tertiles (≤ 22 μmmol/L). It should speak to clinicians and researchers across the multiple diciplines that contribute to this field, including cardiology, oncology, hematology, radiation oncology, surgery, internal medicine, pediatrics, palliative care and geriatrics. Wagener FA, Feldman E, de Witte T, Abraham NG. |, Creative Commons Attribution License (CC BY). Most studies on TBil and coronary artery disease (CAD) have focused on stable CAD. Received: 08 October 2020; Accepted: 24 November 2020; Published: 17 December 2020. doi: 10.1089/1523086041797999, 37. COX-2-derived prostacyclin confers atheroprotection on female mice. support@frontiersin.org. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. See the latest science, research & news from Frontiers, an open access publisher of some of the world's most-cited journals including neuroscience, human neuroscience, immunology, plant science and more. Okuhara K, Kisaka T, Ozono R, Kurisu S, Inoue I, Soga J, et al. Hepatology. doi: 10.3346/jkms.2009.24.S1.S50, 6. (2004) 113:1776–82. Lipid peroxidation plays an important role in the initiation and progression of atherothrombosis in the vascular wall. Previous studies suggested that oxidized stress may cause endothelial dysfunction through the increased production of reactive oxygen species (29, 30). The released heme, which is associated with the pathogenesis of atherosclerosis, can express cellular adhesion molecules and catalyze the oxidation of LDL-C (22–24). Of the 26 Frontiers journals listed in 23 JCR categories, 21 rank in the top 30% most impactful journals. The diagnostic value of the new score model was estimated using the area under the curve (AUC). 3.633. Int J Cardiol. Therefore, it is important to apply this experience to patients with MI undergoing PPCI (43, 44). Few studies have focused on the relationship between the serum TBil levels and short- and long-term clinical outcomes. 7:615254. doi: 10.3389/fcvm.2020.615254. Blood. Exp Biol Med. doi: 10.1161/hc0502.103363, 27. Rispetto allo storico Journal Impact, l'Journal Impact 2018 di Frontiers in Endocrinology è diminuito del 5.47%. This study aimed to establish a score model based on bilirubin for predicting major adverse cardiovascular events (MACEs) and stratify patients to the level of care. Conclusion: The new prediction score model based on TBil could be used in clinical practice to support risk stratification as recommended in the clinical guidelines. (2010) 42:739–48. A total of 3,708 subjects were enrolled (97 patients were lost to follow-up, and 346 had missing bilirubin data) from 4,151 consecutive patients with STEMI. Predicting the risk of death could allow clinicians to pay more attention to the high-risk group and provide them more appropriate medical care; thus, healthcare resources could be allocated and utilized more efficiently. Several epidemiologic researches have demonstrated that serum total bilirubin (TBil) is inversely correlated with the incidence of metabolic syndrome, diabetes mellitus, and hypertension (5–7). The numbers of patients with atrial fibrillation (p = 0.026) and stent implantation (p = 0.016) were higher in the high TBil group than in the low TBil group. The New Frontiers in Cardiovascular Research International Editors’ Symposium was held in Krakow, Poland on 24th and 25th of June 2019.Cardiovascular Research is the Journal for basic and translational science in the ESC Journals family. The management of patients with STEMI early after symptom onset is extremely significant (11, 12). The GUSTO Angiographic investigators. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies. Liu Y, Zhu B, Wang X, Luo L, Li P, Paty DW, et al. doi: 10.1161/01.CIR.0000093660.86242.BB, 32. Manuscripts are peer-reviewed by the Associate and Review Editors of the respective specialty section. Furthermore, we conducted a pairwise comparison of the ROC curve of the TBil-based and GRACE scores (the AUCs were 0.768 and 0.722, respectively; p = 0.0012). Gnanenthiran SR, Kritharides L, D'Souza M, Lowe HC, Brieger DB. Support Center Support Center. Editors. (2019) 123:1244–8. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. The TBil-based score model can be used to predict MACE in patients with STEMI undergoing PPCI. doi: 10.1016/j.ijcard.2017.04.089, 28. Glycative and oxidative stress are associated with altered thrombus composition in diabetic patients with ST-elevation myocardial infarction. Science. Celik T, Kaya MG, Akpek M, Yarlioglues M, Sarli B, Topsakal R, et al. doi: 10.1016/j.amjcard.2012.09.011, 12. Pediatrics. Journal Impact Prediction System provides an open, transparent, and straightforward platform to help academic researchers Predict future Metric and performance through the wisdom of crowds. South Med J. A high TBil level is independently associated with major adverse cardiovascular event (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) at the median 2 year follow-up period. The Journal Impact Quartile of Frontiers in Medicine is Q1. Cardiovascular disease (CVD) remains one of the principal causes of morbidity and mortality in the world. Frontiers in Cardiovascular Medicine publishes peer-reviewed research articles across basic, translational, and clinical cardiovascular medicine. Heme oxygenase-2 is neuroprotective in cerebral ischemia. The cumulative survival rate was significantly higher in the low-risk group than in the medium- and high-risk groups for MACE, all-cause death, cardiac death, recurrent MI, and ischemic stroke. The Cardio-Oncology section of Frontiers in Cardiovascular Medicine is to provide a prime publication platform for this emerging field in medicine. PLUS: Download citation style files for your favorite reference manager. The authors gratefully acknowledge all individuals who participated in this study. Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arterioscler Thromb Vasc Biol. The baseline characteristics of the two groups are summarized in Table 1. The AUCs of the TBil-based and GRACE scores were 0.768 and 0.722, respectively (p = 0.0012). Several studies (32, 33) have observed that bilirubin and its precursor, biliverdin, can inhibit the oxidation of LDL-C, which plays a key role in atherogenesis and can remove reactive oxygen radicals. Second, subjects were enrolled over a long time span; thus, confounding effects that were derived from progress and improvements in medication and interventional techniques may affect the accuracy of the finding. Circ Res. Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells. However, few studies have focused on the relationship between the serum TBil levels during acute stress and short- and long-term clinical outcomes. A prediction score model, with scores ranging from 0 to 500, composed of TBil, age, hypertension history, and other eight variables was developed. Comparison of impact index for the last two years (2018 and 2017) IF of Frontiers in Oncology is decreased by a factor of 0.4 compared to 2017. Coronavirus disease 2019 (COVID-19) severity and mortality have consistently been higher in men compared to women. External link. ... For more information: Frontiers’ Report. Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells. (1). The regression coefficients were converted to integer risk scores, and the final score was the sum of these values. doi: 10.1136/heartjnl-2017-311233, 40. Xu et al. Morita T. Heme oxygenase and atherosclerosis. It is frequently used as a proxy for the relative importance of a journal within its field, with journals with higher impact factors deemed to … Overall, Frontiers journals rank at the 72nd Impact Factor percentile on average and reach as high as the 91st percentile. doi: 10.1161/CIR.0b013e3182742c84, 10. doi: 10.1016/S0165-5728(03)00132-2, 18. Blood samples for bilirubin measurement were obtained on admission and after PPCI. Transplantation. Pairwise comparison of ROC curve of Total bilirubin based score and Grace score. (2001) 21:1373–7. Impact Factors displayed according to category rankings. (34) found that prostacyclin had an antioxidant function in the early atherogenesis period through the induction of HO-1. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal provides a unique forum that helps scientists and clinicians to disseminate novel discoveries and technologies widely, advance scientific knowledge rapidly, and propose new paradigms and theories. (2010) 210:607–13. The cumulative occurrence probability of MACEs at 3 and 5 years can be obtained from the total score on the prediction line at the bottom of the nomogram. Frontiers in Behavioral Neuroscience. Exp Mol Med. Cardiovasc. DOAJ is an online directory that indexes and provides access to … Circ J. 33% scientists expect Frontiers in Physiology Journal Impact 2020 will be in the range of 4.5 ~ 5.0. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. doi: 10.1161/01.ATV.0000135995.39488.6c The Frontiers in Cardiovascular Health varies between and within nations, depend­ ing upon the level at which the battle is fought for better cardiovascular health. doi: 10.1007/BF03401984, 31. doi: 10.1182/blood.V100.3.879, 24. *Correspondence: Hongbing Yan, hbyanfuwai@aliyun.com; hbyanfuwai2018@163.com, Front. The impact factor (IF) 2018 of Frontiers in Bioengineering and Biotechnology is 4.21, which is computed in 2019 as per it's definition.Frontiers in Bioengineering and Biotechnology IF is increased by a factor of 0.24 and approximate percentage change is 6.05% when compared to preceding year 2017, which shows a rising trend. This study confirmed that the Killip classification was an independent risk factor in patients with STEMI who underwent PPCI. Several studies (17, 18) have reported that bilirubin is a potent antioxidant and plays an important role in acute and severe hypoxic injuries, inhibiting nitrous oxide expression and nitric oxide production in response to endotoxin in rats. Eur Heart J. Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: part I: basic mechanisms and in vivo monitoring of ROS. Bilirubin, as an antioxidant, prevents the oxidation of low-density lipoprotein-cholesterol (LDL-C) and plays as a mediator to inhibit anti-inflammatory processes and as a scavenger for oxygen species to resist the cytotoxic effects derived from free heme released by extracellular hemoglobin, especially accompanied by oxidative stress and inflammation (20, 21). Akpek M, Kaya MG, Uyarel H, Yarlioglues M, Kalay N, Gunebakmaz O, et al. doi: 10.1097/SMJ.0b013e3181eac06a, 22. The impact factor (IF) 2018 of Frontiers in Environmental Science is 3.38, which is computed in 2019 as per it's definition.Frontiers in Environmental Science IF is decreased by a factor of 2.62 and approximate percentage change is -43.67% when compared to preceding year 2017, which shows a falling trend. Subsequent studies (36) have suggested that bilirubin can be used for risk stratification in patients with STEMI. A pairwise comparison of the ROC curve of the TBil-based and GRACE scores is shown in Figure 3. Plasma bilirubin and gamma-glutamyltransferase activity are inversely related in dyslipidemic patients with metabolic syndrome: relevance to oxidative stress. Limited by its retrospective design and single-center setting ; however, few studies have the... As drug patents expire be preferred, Barba I, Soga J, Yachie,... An open-access article distributed under the terms of the principal causes of morbidity and mortality in the development of sclerosis! 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